Dihydrostilbene glycosides from Camellia sinensis var. assamica and their cytotoxic activity. Issue 15 (1st August 2022)

• Record Type: Journal Article
• Authors: Cuc, Nguyen Thi; Yen, Duong Thi Hai; Yen, Pham Hai; Hang, Dan Thi Thuy; Tai, Bui Huu; Seo, Yohan; Namkung, Wan; Kim, Seung Hyun; Cuong, Pham Van; Kiem, Phan Van; Nhiem, Nguyen Xuan; Ngoc, Tran Minh
• Is Part Of: Natural product research. Volume 36:Issue 15(2022)
• Page Start: 3931
• Page End: 3937
• Publication Date: 2022-08-01
• Subjects: Camellia sinensis var. assamica -- dihydrostilbene -- cytotoxic activity; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2021.1900844
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Three undescribed dihydrostilbene glycosides, 3, 5-dihydroxyldihydrostilbene 4′- O -[6′′- O -(4′′′-hydroxylbenzoyl)]- β -D-glucopyranoside (1 ), 3, 5-dihydroxyldihydrostilbene 4′- O -(6′′- O -galloyl)- β -D-glucopyranoside (2 ), and 3, 5-dihydroxyldihydrostilbene 4′- O -[6′′- O -(3′′′, 4′′′-dimethoxyl)galloyl]- β -D-glucopyranoside (3 ), and seven known compounds, kaempferol 3- O - β -D-glucopyranoside (4 ), isoquercitrin (5 ), kaempferol 3- O-α -L-rhamnoside (6 ), quercitrin (7), (6 S, 9 R )-roseoside (8 ), (-)-epicatechin 3- O -gallate (9 ), and (-)-epigallocatechin 3- O -gallate (10 ) have been isolated from the methanol extract of the leaves of Camellia sinensis var. assamica (J.W.Mast.) Kitam. (synnonym of Camellia assamica (Mast.) H.T.Chang) (Theaceae). Their structures were elucidated by spectroscopic methods (1 D-, 2 D-NMR) and mass spectra. All compounds were evaluated for cytotoxic activity against human oral cancer (CAL27) and human breast cancer (MDAMB231) cell lines. Compound 10 showed significant cytotoxic activity against CAL27 and MDAMB231 cell lines with IC50 values of 9.78 ± 0.25 and 3.27 ± 0.18 μM, respectively, compared to those of positive control, capecitabine (IC50 values of 8.20 ± 0.75 and 5.20 ± 0.89 μM). Graphical Abstract: UF0001