Brazilian native fruit extracts act as preventive agents modulating the purinergic and cholinergic signalling in blood cells and serum in a rat model of metabolic syndrome. (4th July 2022)

• Record Type: Journal Article
• Authors: Oliveira, Pathise Souto; Soares, Mayara Sandrielly Pereira; Bona, Natália Pontes; da Silva, Pâmela Gonçalves; Mendonça, Lorenço Torres; Vieira, Andriele; Dal-Pizzol, Felipe; Vizzotto, Marcia; Lencina, Claiton Leoneti; Spanevello, Roselia Maria; Stefanello, Francieli Moro
• Is Part Of: Archives of physiology and biochemistry. Volume 128:Number 4(2022)
• Page Start: 993
• Page End: 1000
• Publication Date: 2022-07-04
• Subjects: Highly palatable diet -- natural products -- inflammation -- antithrombotic -- red fruits; Physiology -- Periodicals; Biochemistry -- Periodicals; Biophysics -- Periodicals; Biochemistry; Physiology; 571
• DOI: 10.1080/13813455.2020.1743723
• Languages: English
• ISSNs: 1381-3455

Abstract

Abstract: In this study, we evaluated the effects of native fruit extracts on inflammatory and thromboregulatory parameters in animal model of metabolic syndrome (MetS) induced by highly palatable diet (HPD). Rats were divided into 4 experimental groups: standard chow, HPD, HPD and Psidium cattleianum extract, and HPD and Eugenia uniflora extract. HPD increased serum interleukin-6 (IL-6) levels. On the other hand, this change was prevented by extracts. HPD decreased NTPDase activity in lymphocytes and platelets and 5′-nucleotidase in platelets. Treatment with extracts prevented these changes. An increase in adenosine deaminase (ADA) activity was prevented by E. uniflora in lymphocytes and serum of rats. Fruit extracts prevented the increase in the activity of acetylcholinesterase (AChE) in lymphocytes and butyrylcholinesterase (BuChE) in serum induced by the HPD. Brazilian native fruit extracts have anti-inflammatory and antithrombotic effects, demonstrating therapeutic potential in the prevention of complications associated with MetS.