Ocular Manifestations and Clinical Implications of Serum Immunoglobulin G4 Levels in Graves' Ophthalmopathy Patients. (3rd April 2022)

• Record Type: Journal Article
• Authors: Luo, Ban; Yuan, Xu; Wang, Wei; Zhang, Jing; Liu, Rong; Hu, Weikun; Qi, Xin; Xiang, Nan; Chen, Liwen
• Is Part Of: Ocular immunology and inflammation. Volume 30:Number 3(2022)
• Page Start: 580
• Page End: 587
• Publication Date: 2022-04-03
• Subjects: Graves' ophthalmopathy -- IgG4 -- TRAb -- thyroid autoantibody; Eye -- Diseases -- Immunological aspects -- Periodicals; Eye -- Inflammation -- Periodicals; 617.7
• DOI: 10.1080/09273948.2020.1826537
• Languages: English
• ISSNs: 0927-3948

Abstract

ABSTRACT: Purpose: To investigate the association between serum immunoglobulin G4 (IgG4) levels and laboratorial parameters. Moreover, the ocular manifestations were compared in Graves' ophthalmopathy (GO) patients. Methods: Fifty-seven GO patients and fifty sex- and age-matched euthyroid subjects were enrolled. Serum IgG4 and immunoglobulin G (IgG) levels, thyroid hormones and thyroid autoantibodies were measured in all participants. Ophthalmologic examinations were performed to GO patients. Results: Serum IgG4 levels were increased in GO patients compared with euthyroid subjects (p<0.001). Multivariate analysis showed that TRAb levels were correlated with IgG4 levels in GO patients (β=1.45, p = 0.024). There were eight GO patients with IgG4 levels ≥ 135 mg/dL. They all had both eyelids swelling and the differences of HER were less than 2mm. Seven patients (7/8) showed bilateral symmetrical thickening of the extraocular muscles. Conclusions: Bilateral symmetry of ocular manifestation was observed in GO patients with IgG4 levels ≥135 mg/dL. IgG4 levels may be helpful in monitoring GO and diagnosing a new subtype of GO.