The coffee paradox in stroke: Increased consumption linked with fewer strokes. (8th November 2016)

• Record Type: Journal Article
• Authors: Liebeskind, David S.; Sanossian, Nerses; Fu, Katherine A.; Wang, He-Jing; Arab, Lenore
• Is Part Of: Nutritional neuroscience. Volume 19:Number 9(2016)
• Page Start: 406
• Page End: 413
• Publication Date: 2016-11-08
• Subjects: Coffee -- Caffeine -- Stroke -- Risk factors -- Ischemia; Neuropharmacology -- Periodicals; Diet -- Periodicals; Diet therapy -- Periodicals; Nutrition -- Periodicals; 615.78
• DOI: 10.1179/1476830515Y.0000000035
• Languages: English
• ISSNs: 1028-415X

Abstract

Abstract : Objective : To determine the association in amount of daily coffee consumption with incidence of stroke in a broad cohort, considering other vascular risk factors. Methods : We utilized the Third National Health and Nutrition Examination Survey (1988–1994; NHANES III) data on participants aged ≥17 years old to examine coffee consumption and stroke. Multivariate logistic regression models related the amount of coffee use reported in a food frequency questionnaire with stroke, controlling for other vascular risk factors. Results : Of 33 994 NHANES III subjects, coffee consumption and stroke data in adults ≥17 years old were available in 19 994. Daily coffee consumption ranged from 0 to 20 (median 1) cups and 644 (3.2%) participants had a stroke diagnosed by a physician. Coffee intake varied with age, gender, and ethnicity ( P < 0.001). Interestingly, heart failure, diabetes, and hypertension were less frequent, and high cholesterol more frequent in those consuming ≥3 cups per day ( P < 0.001). Smoking was more frequent in all coffee drinkers ( P < 0.0001). Multivariate analyses revealed an independent effect of heavier coffee consumption (≥3 cups/day) on reduced stroke (OR 0.44, 95% CI 0.22–0.87, P < 0.02) in healthy subjects that was attenuated by vascular risk factors (OR 0.78, 95% CI 0.58–1.07, P ≈ 0.12). Conclusion : Heavier daily coffee consumption is associated with decreased stroke prevalence, despite smoking tendency in heavy coffee drinkers.