The protective effect of Eruca sativa against lipid metabolic abnormalities induced by dioxin in male rats. Issue 1 (31st December 2022)

• Record Type: Journal Article
• Authors: El-Gayar, Hussam A; Salem, Eman T; Edrees, Gamal M
• Is Part Of: Egyptian journal of basic and applied sciences. Volume 9:Issue 1(2022)
• Page Start: 383
• Page End: 392
• Publication Date: 2022-12-31
• Subjects: Eruca sativa -- Dioxin -- lipids; Science -- Periodicals; Technology -- Periodicals; Technology; Science; Science; Electronic journals; Periodicals; Periodical; 505
• DOI: 10.1080/2314808X.2022.2102772
• Languages: English
• ISSNs: 2314-808X

Abstract

ABSTRACT: 2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin (TCDD) is a toxic environmental compound that causes a deleterious effect on lipid metabolism. This study was conducted to evaluate the protective effect of ethanolic Eruca sativa leaves extract against dioxin-induced lipid metabolic abnormalities in male Rattus rattus. For 5 weeks, Eruca sativa leaves extract (500 mg/kg) was co-administered with dioxin (100 ng/kg) daily via gastric intubation. The concomitant treatment with both dioxin and Eruca sativa extract nearly approached the concentration of serum cholesterol, high-density lipoprotein, γ-glutamyltransferase, in addition to testicular concentration of phospholipids, and the activities of both alkaline phosphatase and acid phosphatase activities. In addition, we have noticed a decline in serum concentration of triglycerides, very low- and low-density lipoprotein, total lipid, phospholipid, alkaline phosphatase, acid phosphatase, and lactate dehydrogenase as well as testicular cholesterol, triglyceride, total lipid, γ- glutamyltransferase, and lactate dehydrogenase activities have shown significant (p < 0.05) decreases. Notably, these alterations were not achieved to the control value relative to the dioxin-treated rate. In conclusion, the protective effects of Eruca sativa leaves extract are attributed to its antioxidant effect and fatty acid content.