Fluorogenic sydnonimine probes for orthogonal labeling. Issue 30 (21st March 2022)

• Record Type: Journal Article
• Authors: Xu, Wenyuan; Shao, Zhuzhou; Tang, Cheng; Zhang, Chun; Chen, Yinghan; Liang, Yong
• Is Part Of: Organic & biomolecular chemistry. Volume 20:Issue 30(2022)
• Page Start: 5953
• Page End: 5957
• Publication Date: 2022-03-21
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/d2ob00159d
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : Sydnonimine fluorogenic probes with a high turn-on ratio were designed and synthesized, releasing near-infrared fluorescence via a strain-promoted "click-and-release" reaction. Abstract : A FRET-based fluorescence turn-on probe is designed, which employs a sydnonimine as the linker to match specific fluorophore and quencher pairs and releases the fluorescence after the "click-and-release" reaction. Furthermore, we realized selective fluorescence labeling by exploiting the mutual orthogonality between sydnonimine–DIBAC and tetrazine–1, 3-Cp cycloaddition pairs.