Gambogic acid suppresses the pentose phosphate pathway by covalently inhibiting 6PGD protein in cancer cells. Issue 64 (25th July 2022)

• Record Type: Journal Article
• Authors: Zhu, Yinhua; Zhang, Ying; Zhang, Qianyu; Ma, Ang; Zhang, Ying; Wang, Chen; Gao, Peng; Guo, Qiuyan; Xia, Fei; Tang, Huan; Xu, Chengchao; Wang, Jigang
• Is Part Of: Chemical communications. Volume 58:Issue 64(2022)
• Page Start: 9030
• Page End: 9033
• Publication Date: 2022-07-25
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d2cc03069a
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : Here, we report for the first time the anticancer mechanism of gambogic acid, which covalently inhibits the key rate-limiting enzyme 6PGD in the pentose phosphate pathway, thereby effectively suppressing the metabolic process of cancer cells. Abstract : Whether or not the anticancer activity of gambogic acid is achieved via regulating the cellular metabolic process remains unclear. Here we report that gambogic acid suppresses the pentose phosphate pathway (PPP) by covalently inhibiting the 6-phosphogluconate dehydrogenase (6PGD) protein. This study elucidates the mechanism of action of gambogic acid from the perspective of metabolic reprogramming regulation in cancer cells.