Increased Levels of Soluble ST2 in Patients with Active Newly Diagnosed ANCA-Associated Vasculitis. (23rd February 2015)

• Record Type: Journal Article
• Authors: Hladinova, Z.; Hruskova, Z.; Svobodova, B.; Malickova, K.; Lanska, V.; Konopásek, P.; Jancova, E.; Rysava, R.; Edelstein, C. L.; Tesar, V.
• Other Names: Cantarini Luca Academic Editor.
• Is Part Of: Mediators of inflammation. Volume 2015(2015)
• Publication Date: 2015-02-23
• Subjects: Inflammation -- Mediators -- Periodicals; Biological response modifiers -- Periodicals; Inflammation (Pathologie) -- Médiateurs; Immunomodulateurs; Biological response modifiers; Inflammation -- Mediators; Immunology; Autacoids; Immunologic Factors; Cell Adhesion Molecules; Cell Communication; Cytokines; Inflammation; Periodicals; Electronic journals; 616.0473
• DOI: 10.1155/2015/603750
• Languages: English
• ISSNs: 0962-9351

Abstract

Abstract : Objective . ST2, a member of the interleukin-1 receptor family, is selectively expressed on Th2 cells and mediates important Th2 functions. IL-33 is a specific ligand of ST2. The aim of the study was to determine whether serum levels of soluble ST2 (sST2) or IL-33 predict activity of the disease in patients with ANCA-associated vasculitides (AAV). Methods . 139 AAV patients and 62 controls were studied. IL-33 and sST2 in the blood were measured with a commercially available ELISA. Results . Newly diagnosed AAV patients had higher sST2 levels than controls (P < 0.01 ). Levels of sST2 were significantly higher in active newly diagnosed AAV patients than in patients with remission (P < 0.001 ). IL-33 levels were higher in AAV patients than in the control groups (P = 0.002 ). However, serum IL-33 levels were not increased in patients with active AAV compared to patients in remission. IL-33 levels were higher in patients with granulomatosis with polyangiitis than in patients with microscopic polyangiitis (P = 0.012 ). Conclusions . Serum sST2, but not serum IL-33, may be a marker of activity in AAV patients.