Effect of Single-dose Azithromycin on Pneumococcal Carriage and Resistance: A Randomized Controlled Trial. Issue 9 (23rd May 2022)

• Record Type: Journal Article
• Authors: Coulibaly, Boubacar; Kiemde, Dramane; Zonou, Guillaume; Sié, Ali; Dah, Clarisse; Bountogo, Mamadou; Brogdon, Jessica; Hu, Huiyu; Lebas, Elodie; Porco, Travis C.; Doan, Thuy; Lietman, Thomas M.; Oldenburg, Catherine E.
• Is Part Of: Pediatric infectious disease journal. Volume 41:Issue 9(2022)
• Page Start: 728
• Page End: 730
• Publication Date: 2022-05-23
• Subjects: azithromycin -- antimicrobial resistance -- pneumococcus; Communicable diseases in children -- Periodicals; Infection in children -- Periodicals; 618.929
• DOI: 10.1097/INF.0000000000003585
• Languages: English
• ISSNs: 0891-3668

Abstract

Abstract : We evaluated antibiotic resistance selection in Streptococcus pneumoniae isolates from children participating in an individually randomized trial of single-dose azithromycin versus placebo. After 14 days, the prevalence of resistance to erythromycin, oxacillin, and clindamycin was elevated in the azithromycin versus placebo group. There was no difference at 6 months.