Gastrointestinal Manifestations in Hospitalized Children With Acute SARS-CoV-2 Infection and Multisystem Inflammatory Condition: An Analysis of the VIRUS COVID-19 Registry. Issue 9 (27th May 2022)

• Record Type: Journal Article
• Authors: Sayed, Imran A.; Bhalala, Utpal; Strom, Larisa; Tripathi, Sandeep; Kim, John S.; Michaud, Kristina; Chiotos, Kathleen; Dapul, Heda R.; Gharpure, Varsha P.; Bjornstad, Erica C.; Heneghan, Julia A.; Irby, Katherine; Montgomery, Vicki; Gupta, Neha; Gupta, Manoj; Boman, Karen; Bansal, Vikas; Kashyap, Rahul; Walkey, Allan J.; Kumar, Vishakha K.; Gist, Katja M.
• Is Part Of: Pediatric infectious disease journal. Volume 41:Issue 9(2022)
• Page Start: 751
• Page End: 758
• Publication Date: 2022-05-27
• Subjects: gastrointestinal -- coronavirus disease 2019 -- pediatric -- critical illness; Communicable diseases in children -- Periodicals; Infection in children -- Periodicals; 618.929
• DOI: 10.1097/INF.0000000000003589
• Languages: English
• ISSNs: 0891-3668

Abstract

Abstract : Background: Describe the incidence and associated outcomes of gastrointestinal (GI) manifestations of acute coronavirus disease 2019 (COVID-19) and multisystem inflammatory syndrome in hospitalized children (MIS-C). Methods: Retrospective review of the Viral Infection and Respiratory Illness Universal Study registry, a prospective observational, multicenter international cohort study of hospitalized children with acute COVID-19 or MIS-C from March 2020 to November 2020. The primary outcome measure was critical COVID-19 illness. Multivariable models were performed to assess for associations of GI involvement with the primary composite outcome in the entire cohort and a subpopulation of patients with MIS-C. Secondary outcomes included prolonged hospital length of stay defined as being >75th percentile and mortality. Results: Of the 789 patients, GI involvement was present in 500 (63.3%). Critical illness occurred in 392 (49.6%), and 18 (2.3%) died. Those with GI involvement were older (median age of 8 yr), and 18.2% had an underlying GI comorbidity. GI symptoms and liver derangements were more common among patients with MIS-C. In the adjusted multivariable models, acute COVID-19 was no associated with the primary or secondary outcomes. Similarly, despite the preponderance of GI involvement in patients with MIS-C, it was also not associated with the primary or secondary outcomes. Conclusions: GI involvement is common in hospitalized children with acute COVID-19 and MIS-C. GI involvement is not associated with critical illness, hospital length of stay or mortality in acute COVID-19 or MIS-C.