Diaryliodonium Salts in Transition‐Metal‐Catalyzed Chelation‐Induced C(sp2/sp3)−H Arylations. Issue 12 (1st March 2021)

• Record Type: Journal Article
• Authors: Joshi, Asha; De, Saroj Ranjan
• Is Part Of: European journal of organic chemistry. Issue 12(2021)
• Page Start: 1837
• Page End: 1858
• Publication Date: 2021-03-01
• Subjects: C−H Activation -- Chelation -- C(sp2/sp3)−H arylation -- Diaryliodonium salts -- Transition metals; Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1002/ejoc.202100066
• Languages: English
• ISSNs: 1434-193X

Abstract

Abstract: Transition‐metal‐catalyzed Cross‐coupling via directing group assisted C−H bond activation has become an expedient tool in current synthesis to achieve diverse molecular complexity. In this context, chelation‐assisted arylations of C(sp 2 /sp 3 )−H bonds have been extensively investigated as aryl/biaryl derivatives are an important contributor in the area of the industry, farming, medicinal and material science. The diaryliodonium salt has been broadly utilized in C(sp 2 /sp 3 )−H bond arylation where the reaction proceeds via oxidative addition of aryliodonium salt to chelation induced metallacycle. The proximal/remote C(sp 2 /sp 3 )−H bonds in coordination with transition metals are arylated by a range of directing groups in good to excellent yields. In this mini‐review, we have outlined the up to date developments on transition‐metal‐catalyzed chelation assisted C(sp 2 /sp 3 )−H bond arylation utilizing diaryliodonium salts as the coupling partner. Abstract : Diaryliodonium salts have been extensively studied as coupling partners in directing‐group‐assisted C(sp 2 /sp 3 )−H arylations to obtain aryl/biaryl derivatives. This Minireview summarizes all such developments to provide an overview to the scientific community for further advancements in this area.