Copper‐Catalyzed Difluoroalkylation‐Thiolation of Alkenes Promoted by Na2S2O5. Issue 12 (22nd March 2021)

• Record Type: Journal Article
• Authors: Gao, Bao; Ni, Yingjie; Liu, Xiaojun; Jiang, Tao; Yan, Qian; Yang, Ruiting; Zhang, Xiuli
• Is Part Of: European journal of organic chemistry. Issue 12(2021)
• Page Start: 1913
• Page End: 1918
• Publication Date: 2021-03-22
• Subjects: Copper -- Homogeneous catalysis -- Multicomponent reactions -- Synthetic methods; Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1002/ejoc.202100091
• Languages: English
• ISSNs: 1434-193X

Abstract

Abstract: A novel and convenient protocol for the difluoroalkylation‐thiolation of alkenes catalyzed by Cu/Na2 S2 O5 system has been developed. This reaction was carried out using readily available starting materials under mild conditions, wherein the C−C and C−S bonds simultaneously were constructed smoothly. The reaction features broad substrate scope of alkenes and disulfides, good functional group tolerance, and good to excellent yields with high selectivity. Abstract : We report an efficient protocol for the difluoroalkylation‐thiolation of alkenes catalyzed by Cu/Na2 S2 O5 system with disulfides as a sulfur source. This reaction allows a variety of alkenes and disulfides, wherein the new C−C and C−S bonds were simultaneously constructed.