Disseminated intravascular coagulopathy: a complication of Stevens–Johnson syndrome/toxic epidermal necrolysis. (17th December 2020) - el‐Azhary, Rokea A.
Abstract: Background: The purpose of this study was to retrospectively assess clinical characteristics and mortality rate of Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) in patients who developed disseminated intravascular coagulation (DIC). Methods: A systematic retrospective chart review of all patients with concurrent clinical diagnosis of DIC and SJS/TEN between July 1, 2012, and January 1, 2020, at the Mayo Clinic was performed. Results: The incidence of DIC in patients with SJS/TEN was 1.3% at our institution (5 of 396 DIC patients). Triggers of SJS/TEN included lamotrigine, clofarabine, antibiotics, and sepsis. Two patients diagnosed with SJS and two patients with TEN succumbed to the disease. Conclusion: DIC is a rare underlying risk in patients with SJS/TEN and is associated with increased mortality. Early clinician awareness and aggressive intervention is advised.