Acidic polysaccharides of Mountain Cultivated Ginseng: The potential source of anti-fatigue nutrients. (August 2022)

• Record Type: Journal Article
• Authors: Yu, Yang; Liu, Hao; Nie, Jianing; Tan, Jialiang; Lv, Chongning; Lu, Jincai
• Is Part Of: Journal of functional foods. Volume 95(2022)
• Publication Date: 2022-08
• Subjects: Anti-fatigue -- Acidic polysaccharides -- Mountain Cultivated Ginseng -- AMPK signaling pathway; MCG mountain cultivated ginseng -- CG cultivated ginseng -- MCGCe mountain cultivated ginseng crude extracts -- CGCe cultivated ginseng crude extracts -- MCGSa mountain cultivated ginseng saponins -- CGSa cultivated ginseng saponins -- MCGPs mountain cultivated ginseng polysaccharides -- CGPs cultivated ginseng polysaccharides -- MCGPr mountain cultivated ginseng protein -- CGPr cultivated ginseng protein -- MCGNPs mountain cultivated ginseng neutral polysaccharides -- CGNPs cultivated ginseng neutral polysaccharides -- MCGAPs mountain cultivated ginseng acidic polysaccharides -- CGAPs cultivated ginseng acidic polysaccharides -- Man mannose -- Rha rhamnose -- GlcA glucuronic acid -- GalA galacturonic acid -- Glc glucose -- Gal galactose -- Xyl xylose -- Ara arabinose -- BLA blood lactate -- LDH lactate dehydrogenase -- BUN blood urea nitrogen -- CAT catalase -- SOD superoxide dismutase -- MDA malondialdehyde -- CK creatine kinase -- LKB1 Liver kinase B1 -- AMPK adenosine 5'-monophosphate (AMP)-activated protein kinase -- PGC-1α peroxisome proliferator-activated receptor-γ coactlvator-1α -- GLUT4 glucose transporter 4 -- PVDF polyvinylidene difluoride -- BCA Bicinchoninic acid; Functional foods -- Analysis -- Periodicals; Food -- Biotechnology -- Periodicals; Nutrition -- Periodicals; 613.2
• DOI: 10.1016/j.jff.2022.105198
• Languages: English
• ISSNs: 1756-4646

Abstract

Graphical abstract: Highlights: MCGAPs is a potential anti-fatigue nutrient. MCGAPs can eliminate the excessive accumulation of metabolites. MCGAPs can relieve oxidative stress damage. MCGAPs can modify the kinetics of energy substrates mobilization. MCGAPs relieved fatigue by regulating AMPK axis signaling pathway. Abstract: Ginseng is usually considered as a functional food and herbal medicine, and it has anti-fatigue activity, which is of great attention and expectation. Based on the comparison of Mountain Cultivated Ginseng (MCG) with Cultivated Ginseng (CG), this study aimed to explore the material basis and mechanism of Ginseng in anti-fatigue effects. The results showed that the Mountain Cultivated Ginseng acidic polysaccharides (MCGAPs) had obvious advantages, which significantly prolonged the fatigue tolerance time, alleviated the accumulation of BLA, LDH, BUN and MDA, increased the activities of SOD, CAT and CK, regulated glycolysis and alleviated muscle fiber contraction. It also significantly upregulated the expression of AMPK axis related proteins in mice muscle. Preliminary results exhibited the anti-fatigue effect of MCG was significantly better than CG, which was mainly due to the difference of acidic polysaccharide. The findings supported the potential of MCGAPs to be used as a functional ingredient for anti-fatigue.