Analgesia Synergism of Essential Oil from Pericarp of Zanthoxylum schinifolium and Verapamil. (8th July 2014)

• Record Type: Journal Article
• Authors: Wu, Gao; Wu, Hanbin
• Other Names: Kanfer Isadore Academic Editor.
• Is Part Of: Evidence-based complementary and alternative medicine. Volume 2014(2014)
• Publication Date: 2014-07-08
• Subjects: Alternative medicine -- Periodicals; 615.505
• DOI: 10.1155/2014/505876
• Languages: English
• ISSNs: 1741-427X

Abstract

Abstract : Objective . To evaluate the synergistic analgesic effect of essential oil of Zanthoxylum schinifolium Sieb. et Zucc. (EOZ) and verapamil (Ver). Method . The qualitative and quantitative composition of EOZ were determined with gas chromatography/Mass spectrometer. The interaction between EOZ and Ver in antinociceptive activity was evaluated by using acetic acid-induced writhing, hot plate, and tail flick tests in mice and in isolated toad sciatic nerve test. Results . Linalool, limonene, and sabinene are the major components of EOZ. EOZ (middle-dose: 40 mg·kg −1, high-dose: 80 mg·kg −1 ) and EOZ + Ver (Each dose group) have remarkable analgesic effects on pain in mice induced by acetic acid-induced writhing, hot plate, and tail flick tests. Low-dose EOZ (20 mg·kg −1 ) had no analgesic action, but when it is combined with Ver it has shown significant antinociception. Verapamil has a faint analgesic effect but was not able to inhibit action potential transmission in toad sciatic nerve. EOZ (0.2%) and EOZ + Ver (0.2% + 0.05%) also inhibited action potential transmission in toad sciatic nerve. Combination of EOZ with Ver had a greater analgesic effect and inhibition of nerve action potential transmission compared to its components EOZ and Ver. Conclusion . The combination of EOZ with Ver produces a synergistic analgesic effect.