A nutrigenetic approach to examine the relationship between vitamin B12 status and cardio‐metabolic traits in multiple ethnic groups – findings from the GeNuIne Collaboration. Issue 2 (9th April 2021)

• Record Type: Journal Article
• Authors: Surendran, S.; Vimaleswaran, K. S.
• Is Part Of: Nutrition bulletin. Volume 46:Issue 2(2021)
• Page Start: 185
• Page End: 194
• Publication Date: 2021-04-09
• Subjects: GRS -- metabolic traits -- nutrigenetics -- obesity -- SNP -- vitamin B12 pathway; Nutrition -- Periodicals; 613.2
• DOI: 10.1111/nbu.12494
• Languages: English
• ISSNs: 1471-9827

Abstract

Abstract: Low vitamin B12 concentration has been shown to be a risk factor for cardio‐metabolic traits in numerous observational studies; however, the relationship has remained inconsistent. It is possible that certain genotypes jointly contribute to cardio‐metabolic diseases and vitamin B12 deficiency, and these may be modulated by dietary factors. The main objective of this article is to summarise the findings from the GeNuIne (Ge ne‐Nu trient In te ractions) Collaboration on the effect of gene–nutrient interactions on vitamin B12 concentrations and cardio‐metabolic disease risk factors in population‐based studies from different ethnic groups. Interactions between vitamin B12‐related single‐nucleotide polymorphisms (SNPs) and protein energy intake (%) on waist circumference ( P interation =0.002) and body fat percentage ( P interaction =0.034) were observed in Sri Lankan and Indonesian populations, respectively. In the study in Brazilian adolescents, the metabolic and vitamin B12‐related SNPs showed a significant interaction with dietary carbohydrate and protein intakes on oxidised low‐density lipoprotein cholesterol and homocysteine concentrations, respectively. In the Asian Indian population, an association between obesity‐related SNPs and vitamin B12 concentrations ( p = 0.018) was observed. In summary, these studies in multiple ethnic groups show that the association between genetically low vitamin B12 concentrations and cardio‐metabolic traits may be modified by dietary intake. Further studies utilising larger sample sizes are needed to confirm or refute our findings.