Association of time in range with hemoglobin A1c, glycated albumin and 1, 5‐anhydro‐d‐glucitol. Issue 6 (15th November 2020)

• Record Type: Journal Article
• Authors: Ohigashi, Mana; Osugi, Keiko; Kusunoki, Yoshiki; Washio, Kahori; Matsutani, Satoshi; Tsunoda, Taku; Matsuo, Toshihiro; Konishi, Kosuke; Katsuno, Tomoyuki; Namba, Mitsuyoshi; Koyama, Hidenori
• Is Part Of: Journal of diabetes investigation. Volume 12:Issue 6(2021)
• Page Start: 940
• Page End: 949
• Publication Date: 2020-11-15
• Subjects: Continuous glucose monitoring -- Hemoglobin A1c -- Time in range; Diabetes -- Periodicals; Diabetes -- Research -- Periodicals; Diabetes Mellitus -- Periodicals; 616.462005
• DOI: 10.1111/jdi.13437
• Languages: English
• ISSNs: 2040-1116

Abstract

Abstract: Aims/Introduction: Hemoglobin A1c (HbA1c), glycated albumin (GA) and 1, 5‐anhydro‐d ‐glucitol (1, 5‐AG) are used as indicators of glycemic control, whereas continuous glucose monitoring (CGM) is used to assess daily glucose profiles. The aim of this study was to investigate the relationships between CGM metrics, such as time in range (TIR), and glycemic control indicators. Materials and Methods: We carried out retrospective CGM and blood tests on 189 outpatients with impaired glucose tolerance ( n = 22), type 1 diabetes mellitus ( n = 67) or type 2 diabetes mellitus ( n = 100). Results: In type 1 diabetes mellitus and type 2 diabetes mellitus patients, HbA1c and GA were negatively correlated with TIR, whereas 1, 5‐AG was positively correlated with TIR. In type 1 diabetes mellitus patients, a TIR of 70% corresponded to HbA1c, GA and 1, 5‐AG of 6.9% (95% confidence interval [CI] 6.5–7.2%), 20.3% (95% CI 19.0–21.7%) and 6.0 µg/mL (95% CI 5.1–6.9 µg/mL), respectively. In type 2 diabetes mellitus patients, a TIR of 70% corresponded to HbA1c, GA and 1, 5‐AG of 7.1% (95% CI 7.0–7.3%), 19.3% (95% CI 18.7–19.9%) and 10.0 µg/mL (95% CI 9.0–11.0 µg/mL), respectively. TIR values corresponding to HbA1c levels of 7.0% were 56.1% (95% CI 52.3–59.8%) and 74.2% (95% CI 71.3–77.2%) in type 1 diabetes mellitus and type 2 diabetes mellitus patients, respectively. Conclusions: The results of this study showed that the estimated HbA1c corresponding to a TIR of 70% was approximately 7.0% for both type 1 diabetes mellitus and type 2 diabetes mellitus patients, and that the estimated 1, 5‐AG calculated from the TIR of 70% might be different between type 1 diabetes mellitus and type 2 diabetes mellitus patients. Abstract : Hemoglobin A1c was the most useful explanatory factor for mean sensor glucose levels. Glycated albumin was the most useful explanatory factor for glycemic variability and time in range.