Molecular mechanisms of the antibacterial activity of polyimide fibers in a skin-wound model with Gram-positive and Gram-negative bacterial infection in vivo. Issue 14 (21st June 2022)

• Record Type: Journal Article
• Authors: Yang, Xia; Ma, Wei; Lin, Hua; Ao, Shengxiang; Liu, Haoru; Zhang, Hao; Tang, Wanqi; Xiao, Hongyan; Wang, Fangjie; Zhu, Junyu; Liu, Daoyan; Lin, Shujun; Zhang, Ying; Zhou, Zhongfu; Chen, Changbin; Liang, Huaping
• Is Part Of: Nanoscale advances. Volume 4:Issue 14(2022)
• Page Start: 3043
• Page End: 3053
• Publication Date: 2022-06-21
• Subjects: 620.5
• DOI: 10.1039/d2na00221c
• Languages: English
• ISSNs: 2516-0230

Abstract

Abstract : A novel natural polyimide fiber was identified and displayed significant antibacterial activity against E. coli and MRSA in vitro and in vivo, may act as a promising candidate for antimicrobial material for trauma and surgical applications. Abstract : Recently, the need for antibacterial dressings has amplified because of the increase of traumatic injuries. However, there is still a lack of ideal, natural antibacterial dressings that show an efficient antibacterial property with no toxicity. Polyimide (PI) used as an implantable and flexible material has been recently reported as a mixture of particles showing more desirable antibacterial properties. However, we have identified a novel type of natural polyimide (PI) fiber that revealed antibacterial properties by itself for the first time. The PI fiber material is mainly composed of C, N, and O, and contains a small amount of Ca and Cl; the characteristic peaks of polyimide appear at 1774 cm −1, 1713 cm −1, 1370 cm −1, 1087 cm −1, and 722 cm −1 . PI fibers displayed significant antibacterial activities against Escherichia coli (as a Gram-negative bacteria model) and methicillin-resistant Staphylococcus aureus (MRSA, as a Gram-positive bacteria model) according to the time-kill kinetics in vitro, and PI fibers damaged both bacterial cell walls directly. PI fibers efficiently ameliorated a local infection in vivo, inhibited the bacterial burden, decreased infiltrating macrophages, and accelerated wound healing in an E. coli - or MRSA-infected wound model. In conclusion, PI fibers used in the present study may act as potent antibacterial dressings protecting from MRSA or E. coli infections and as promising candidates for antimicrobial materials for trauma and surgical applications.