Analysis of retention of gadolinium by brain, bone, and blood following linear gadolinium‐based contrast agent administration in rats with experimental sepsis. Issue 6 (1st November 2019)

• Record Type: Journal Article
• Authors: Damme, Nikolas M.; Fernandez, Diego P.; Wang, Li‐Ming; Wu, Qi; Kirk, Ryan A.; Towner, Rheal A.; McNally, J. Scott; Hoffman, John M.; Morton, Kathryn A.
• Is Part Of: Magnetic resonance in medicine. Volume 83:Issue 6(2020)
• Page Start: 1930
• Page End: 1939
• Publication Date: 2019-11-01
• Subjects: bone -- brain -- deposition -- gadolinium -- lipopolysaccharide -- sepsis; Nuclear magnetic resonance -- Periodicals; Electron paramagnetic resonance -- Periodicals; 616.07548
• DOI: 10.1002/mrm.28060
• Languages: English
• ISSNs: 0740-3194

Abstract

Abstract : Purpose: It is important to identify populations that may be vulnerable to the brain deposition of gadolinium (Gd) from MRI contrast agents. At intervals from 24 hours to 6 weeks following injection of a linear Gd contrast agent, the brain, blood and bone content of Gd were compared between control rats and those with experimental endotoxin‐induced sepsis that results in neuroinflammation and blood–brain barrier disruption. Methods: Male rats were injected intraperitoneally with 10 mg/kg lipopolysaccharide. Control animals received no injection. Twenty‐four hours later, 0.2 mmol/kg of gadobenate dimeglumine was injected intravenously. Brain, blood, and bone Gd levels were measured at 24 hours, 1 week, 3 weeks, and 6 weeks by inductively coupled plasma mass spectroscopy. Results: Blood Gd decreased rapidly between 24 hours and 1 week, and thereafter was undetectable, with no significant difference between lipopolysaccharide and control rats. Brain levels of Gd were significantly higher (4.29‐2.36‐fold) and bone levels slightly higher (1.35‐1.11‐fold) in lipopolysaccharide than control rats at all time points with significant retention at 6 weeks. Conclusion: Experimental sepsis results in significantly higher deposition of Gd in the brain and bone in rats. While blood Gd clears rapidly, brain and bone retained substantial Gd even at 6 weeks following contrast injection.