An adaptive regularization algorithm for recovering the rate constant distribution from biosensor data. Issue 10 (3rd October 2018)

• Record Type: Journal Article
• Authors: Zhang, Y.; Forssén, P.; Fornstedt, T.; Gulliksson, M.; Dai, X.
• Is Part Of: Inverse problems in science and engineering. Volume 26:Issue 10(2018)
• Page Start: 1464
• Page End: 1489
• Publication Date: 2018-10-03
• Subjects: Rate constant distribution -- inverse problem -- regularization -- adaptive finite element -- a posteriori error estimation; 35R25 -- 35R30 -- 65M32 -- 65M60 -- 65K15; Engineering mathematics -- Periodicals; Inverse problems (Differential equations) -- Periodicals; 620.001515357
• DOI: 10.1080/17415977.2017.1411912
• Languages: English
• ISSNs: 1741-5977

Abstract

Abstract: We present here the theoretical results and numerical analysis of a regularization method for the inverse problem of determining the rate constant distribution from biosensor data. The rate constant distribution method is a modern technique to study binding equilibrium and kinetics for chemical reactions. Finding a rate constant distribution from biosensor data can be described as a multidimensional Fredholm integral equation of the first kind, which is a typical ill-posed problem in the sense of J. Hadamard. By combining regularization theory and the goal-oriented adaptive discretization technique, we develop an Adaptive Interaction Distribution Algorithm (AIDA) for the reconstruction of rate constant distributions. The mesh refinement criteria are proposed based on the a posteriori error estimation of the finite element approximation. The stability of the obtained approximate solution with respect to data noise is proven. Finally, numerical tests for both synthetic and real data are given to show the robustness of the AIDA.