Prediction of central compartment nodal metastases in papillary thyroid cancer using TI-RADS score, blood flow, and multifocality. (October 2022)

• Record Type: Journal Article
• Authors: Yang, Jin-Ru; Song, Yan; Chang, Shu-Juan; Shi, Li-Li
• Is Part Of: Acta radiologica. Volume 63:Number 10(2022)
• Page Start: 1374
• Page End: 1380
• Publication Date: 2022-10
• Subjects: Papillary thyroid cancer -- lymph node metastasis -- ultrasound -- ACR TI-RADS; Radiology, Medical -- Periodicals; Radiography, Medical -- Periodicals; Radiotherapy -- Periodicals; 616.0757
• DOI: 10.1177/02841851211041811
• Languages: English
• ISSNs: 0284-1851

Abstract

Background: The relationship between the American College of Radiology (ACR) Thyroid Imaging Reporting and Data System (TI-RADS) and the risk of lymph node metastases in papillary thyroid cancer (PTC) could improve the detection rate of lymph node metastases in thyroid cancer and provide a scientific basis for clinical diagnosis. Purpose: To evaluate the risk of lymph node metastases of PTC associated with the score from ACR TI-RADS adjusted for other correlative factors. Material and Methods: A total of 560 patients with pathologically confirmed PTC were included in the study and classified into a metastases group and a non-metastases group. Clinical and pathological manifestations of the patients were collected. Results: The median TI-RADS score was 13 (p25 –p75 = 11–14) among the patients with lymph node metastases, higher than those without metastases 9 (8–10) ( P < 0.001). Multiple logistic regression indicated that TI-RADS score (odds ratio [OR] = 2.204), male sex (OR = 2.376), multifocality (OR = 4.170), and rich blood flow (OR = 3.656) were risk factors for lymph node metastases in patients with thyroid carcinoma. Some related factors such as TI-RADS score, age(<45years old), male, multifocality and rich blood flow were related to lymph node metastases in the central area of the neck which could provide therapeutic strategy for further treatment. Conclusion: it is not just the TI-RADS score but also multifocality, blood flow, and sex that influence the prediction of the risk of PTC central lymph node metastases.