Effects of Huangjiu, Baijiu and Red Wine Combined With High-Fat Diet on Glucose and Lipid Metabolism: Aggravate or Alleviate?. (26th October 2020)

• Record Type: Journal Article
• Authors: Zhao, Liang; Ouyang, Hanying; Zhang, Nanhai; Wang, Chengtao; Ji, Baoping; Zhou, Feng
• Is Part Of: Alcohol and alcoholism. Volume 56:Number 3(2021)
• Page Start: 334
• Page End: 347
• Publication Date: 2020-10-26
• Subjects: Alcoholism -- Periodicals; 616.861005
• DOI: 10.1093/alcalc/agaa097
• Languages: English
• ISSNs: 0735-0414

Abstract

Abstract: Aim: To compare effects on certain health indices in rodents of different doses of alcoholic beverages, huangjiu (Chinese yellow wine), red wine and baijiu (Chinese liquor) combined with high-fat diet (HFD) and the pure HFD. Methods: A total of 80 rats were randomly divided into eight groups and treated with (a) basal diet (3.5 kcal/g); (b) HFD (19.5% w/w lard, 4.5 kcal/g) and (c) HFD with low or high doses of separate alcoholic beverages (2.5 and 5 g/kg ethanol, respectively) for 28 weeks. Results: Chronic drinking when combined with HFD was associated with reduced body weight, fat accumulation and serum TNF-α level, serum TG, TC and LDL-C levels, and improved glucose tolerance (OGTT) and insulin sensitivity (ITT), hepatic enzymes; elevated levels or activities of the antioxidant enzymes like superoxide dismutase, catalase and glutathione reductase, reduced the content of lipid peroxidation productions such as malondialdehyde, in comparison with the pure HFD intake. In addition, compared with HFD, drinking plus HFD improved microbiota dysbiosis, down-regulated the ratio of Firmicutes / Bacteroidetes and promoted the growth of some probiotics including Prevotellaceae_UCG-001 and norank_f__Bacteroidales_S24-7_group . Conclusion: Overall, the three beverages showed different impacts on indicators but red wine showed the most 'beneficial' effects. Of course, higher ethanol dosages can be expected to cause overall negative health effects, and harms of high fat intake can be prevented by healthier diet. Abstract : Short Summary: When a high fat diet is taken, sustained alcohol consumption could reduce the effects on body weight, fat accumulation and serum TNF-α level, blood lipid, improve glucose tolerance and insulin sensitivity, alleviate hepatic enzyme abnormalities, elevate hepatic antioxidant activity and reduce lipid peroxidation in liver. However, in larger amounts we recognize that alcohol harms overall health and high-fat diets can be avoided.