Accumulation of short-, medium-, and long- chain chlorinated paraffins in tissues of laying hens after dietary exposure. (30th July 2021) - Mézière, Marie
Highlights: 21 laying hens dietary exposed to SCCP, MCCP and LCCP mixtures for up to 91 days. All CPs detected in liver, showing a gastro-intestinal barrier crossing. SCCPs and MCCPs reached more easily the internal tissues than LCCPs. CPs affinity was differentiated between low and high perfusion rate matrices. An uneven mass balance suggested a potential biodegradation of CPs. Abstract: Reliable human health risk assessment associated with chlorinated paraffins (CPs) exposure is limited by the lack of data on the fate of this complex family of contaminants. To gain knowledge on the accumulation and distribution of CPs in biota after ingestion, laying hens were dietary exposed to technical mixtures of short- (SCCPs), medium- (MCCPs), or long-chain (LCCPs) CPs of various chlorine contents during 91 days, at 200 ng/g of feed, each. Adipose tissue, liver, muscle and serum were collected at the steady-state, along with excreta. All C10 -C36 CPs were detected in liver. However, differences were observed in CP distribution: LCCPs high %Cl were retained in the liver; LCCPs low %Cl circulated through the serum and were distributed in the different compartments, but were mostly excreted through the eggs; SCCPs and MCCPs were found in all tissues at similar levels. Finally, a mass balance indicated a potential for biotransformation.