Characteristics of early sacubitril/valsartan patients and considerations for studies in electronic health record data. (29th August 2018)

• Record Type: Journal Article
• Authors: Gagne, Joshua J; Tsacogianis, Theodore; Bruce Wirta, Sara; Rogers, James R; Calado, Frederico; Chang, Chun-Lan; Turner, Stuart J; Schlienger, Raymond G; Balas, Bogdan; Abdurrob, Abdurrahman; Najafzadeh, Mehdi; Wang, Shirley V
• Is Part Of: Journal of comparative effectiveness research. Volume 7:Number 11(2018)
• Page Start: 1073
• Page End: 1082
• Publication Date: 2018-08-29
• Subjects: cardiology/cardiovascular -- heart failure -- observational research -- outcomes research -- sacubitril/valsartan -- utilization; Medical care -- Research -- Periodicals; Medical care -- Research -- Evaluation -- Periodicals; Medical care -- Decision making -- Periodicals; Evidence-based medicine -- Periodicals; Medicine, Comparative -- Periodicals; 362.1072
• DOI: 10.2217/cer-2017-0088
• Languages: English
• ISSNs: 2042-6305

Abstract

Aim: We examined characteristics of early sacubitril/valsartan users in a large US electronic health records database.Patients & methods: We identified three cohorts of patients with heart failure (HF): sacubitril/valsartan patients with a prior HF diagnosis; patients with HF with reduced ejection fraction; and patients with HF treated with an angiotensin-converting enzyme inhibitor or angiotensin II receptor blocker and a β-blocker.Results: Sacubitril/valsartan patients were younger than patients in the other cohorts; the mean age of sacubitril/valsartan patients increased by 2 years in the first 15 months of marketing. Most sacubitril/valsartan patients had prior use of HF treatment.Conclusion: Overall, sacubitril/valsartan patients resembled those in the HF with reduced ejection fraction cohort, and commonly used other drugs for HF.