STK24 expression is modulated by DNA copy number/methylation in lung adenocarcinoma and predicts poor survival. (20th March 2018)

• Record Type: Journal Article
• Authors: Huang, Ningyu; Lin, Wenbo; Shi, Xiuyu; Tao, Tao
• Is Part Of: Future oncology. Volume 14:Number 22(2018)
• Page Start: 2253
• Page End: 2263
• Publication Date: 2018-03-20
• Subjects: copy number -- lung adenocarcinoma -- methylation -- prognosis -- STK24; Oncology -- Periodicals; 616.99405
• DOI: 10.2217/fon-2018-0126
• Languages: English
• ISSNs: 1479-6694

Abstract

Aim: To explore the independent prognostic value of STK24 expression in terms of overall survival and recurrence-free survival and the potential mechanisms of its dysregulation in non-small-cell lung adenocarcinoma.Patients & methods: Data were from the Cancer Genome Atlas-lung adenocarcinoma.Results: Increased STK24 expression was an independent prognostic indicator of unfavorable overall survival (Hazard ratio: 1.478; 95% CI: 1.149–1.901; p < 0.002) and recurrence-free survival (Hazard ratio: 1.855; 95% CI: 1.399–2.458; p < 0.001). DNA amplification was associated with significantly upregulated STK24 expression. There was a weak negative correlation between STK24 expression and its DNA methylation (Pearson's r = -0.32).Conclusion: Aberrant STK24 expression was an independent prognostic indicator in lung adenocarcinoma patients. Its dysregulation was associated with its DNA copy number alteration and methylation.