Sex differences in underweight and body mass index in Chinese early de novo patients with Parkinson's disease. Issue 12 (16th October 2020)

• Record Type: Journal Article
• Authors: Wu, Qing; Liu, Meizhen; Yu, Ming; Fu, Jianfei
• Is Part Of: Brain and behavior. Volume 10:Issue 12(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-10-16
• Subjects: body mass index -- Chinese -- de novo -- Parkinson's disease -- sex differences -- underweight; Neurology -- Periodicals; Neurosciences -- Periodicals; Psychology -- Periodicals; Psychiatry -- Periodicals; 616.8005
• DOI: 10.1002/brb3.1893
• Languages: English
• ISSNs: 2162-3279

Abstract

Abstract: Objective: There have been studies investigating sex differences in clinical manifestation of Parkinson's disease (PD). However, sex differences in underweight and body mass index (BMI) in de novo PD patients lacked systematic study. We aimed to compare sex differences in clinical features and related factors of underweight and BMI in Chinese de novo PD patients. Materials and Methods: A total of 253 untreated PD inpatients and 218 controls were recruited from Ningbo. BMI, demographics, Montreal Cognitive Assessment (MoCA), supine and upright blood pressure, Hamilton Anxiety Scale (HAMA), Hamilton Depression Scale (HAMD), homocysteine (HCY), uric acid, glycated hemoglobin, and lipid parameters were examined. Patients were assessed using the Unified Parkinson's Disease Rating Scale (UPDRS) motor scores and Hoehn and Yahr (HY) Rating Scale. Results: Female patients had a significantly lower incidence of underweight and higher BMI than male patients, and there were sex differences in serum lipids, HCY levels, and depression severity. Binary regression analysis showed that only in male patients was underweight associated with the UPDRS motor score and lower ΔSBP and ΔDBP values (all p < .05). Further multiple regression analysis indicated, in addition to the correlations between BMI and ΔSBP and ΔDBP values in both sexes (all p < .001), BMI was also associated with MoCA and lower UPDRS motor scores in male patients and lower HAMD scores in female patients. Conclusion: Our study suggests that there are significant sex differences in the prevalence of underweight, BMI, and factors associated with underweight and BMI among de novo PD patients. Abstract : Sex differences in underweight and body mass index in Chinese early de novo patients with Parkinson's disease (PD) have not been investigated before, our study suggests that there are significant sex differences in the prevalence of underweight, body mass index (BMI), and factors associated with underweight and BMI among de novo PD patients; therefore, sex‐specific management strategies such as dietary structure, physical activity, and nutritional status interventions may have certain clinical significance for improving life quality and prognosis of patients.