Effects of cellular senescence on metabolic pathways in non-immune and immune cells. (March 2021)

• Record Type: Journal Article
• Authors: Frasca, Daniela; Saada, Yara Bou; Garcia, Denisse; Friguet, Bertrand
• Is Part Of: Mechanisms of ageing and development. Volume 194(2021)
• Publication Date: 2021-03
• Subjects: AMP adenosine monophosphate -- AMPK AMP-activated protein kinase -- ADP adenosine diphosphate -- ATP adenosine triphosphate -- BCR B cell receptor -- DN Double negative -- ECAR extracellular acidification rate -- EGF epithelium growth factor -- FA fatty acid -- FOXO1 Forkhead box protein O1 -- HODE hydroxyoctadecadienoic acid -- HUVEC human umbilical vein endothelial cell -- IR insulin resistance -- LIMS Laboratory Information Management System -- MAPK mitogen-activated protein kinase -- NAD nicotinamide adenine dinucleotide phosphate -- NADP nicotinamide adenine dinucleotide phosphate -- NAMPT nicotinamide phosphoribosyltransferase -- NF-KB nuclear factor-kappa B -- NGF nerve growth factor -- NK Natural killer -- NKR Natural killer receptor -- OCR oxygen consumption rate -- OXPHOS oxidative phosphorylation -- QC quality control -- ROS reactive oxygen species -- SASP senescence-associated secretory phenotype -- SAT subcutaneous adipose tissue -- TCA tricarboxylic acid -- TCR T cell receptor -- TNF tumor necrosis factor -- VEGF vascular endothelial growth factor; Cellular senescence -- Metabolism -- Non-immune cells -- Immune cells; Aging -- Periodicals; Developmental biology -- Periodicals; Aging -- Periodicals; Developmental Biology -- Periodicals; Vieillissement -- Périodiques; Biologie du développement -- Périodiques; Aging; Developmental biology; Periodicals; 612.67
• DOI: 10.1016/j.mad.2020.111428
• Languages: English
• ISSNs: 0047-6374

Abstract

Highlights: Senescent cells are metabolically active. Cellular senescence induces metabolic changes in non-immune and immune cells. Senescent cells are flexible in the use of different metabolic pathways. Metabolic reprogramming in senescent cells leads to increased survival and supports function. Abstract: Many cellular stresses induce cellular senescence and the irreversible arrest of cell proliferation in different cell types. Although blocked in their capacity to divide, senescent cells are metabolically active and are characterized by a different metabolic phenotype as compared to non-senescent cells. Changes observed in senescent cells depend from the cell type and lead to an adaptative flexibility in the type of metabolism. This metabolic reprogramming is needed to cope with survival and with the energetic demands of the senescent program that include the increased secretion of senescence-associated secretory phenotype factors.