Cellular senescence in vivo: From cells to tissues to pathologies. (September 2020)

• Record Type: Journal Article
• Authors: Kumar, Avadh; Bano, Daniele; Ehninger, Dan
• Is Part Of: Mechanisms of ageing and development. Volume 190(2020)
• Publication Date: 2020-09
• Subjects: In vivo senescence -- Senescent cell types -- Aging -- Age-Related diseases -- SASP; Aging -- Periodicals; Developmental biology -- Periodicals; Aging -- Periodicals; Developmental Biology -- Periodicals; Vieillissement -- Périodiques; Biologie du développement -- Périodiques; Aging; Developmental biology; Periodicals; 612.67
• DOI: 10.1016/j.mad.2020.111308
• Languages: English
• ISSNs: 0047-6374

Abstract

Highlights: Recent data in animal models indicate that cellular senescence plays important roles in the pathogenesis of a range of aging-associated disorders. While senescence is often studied in cell culture, less information is available regarding senescence and its associated states in vivo . Here, we review data available to indicate which cell types can undergo senescence within various mammalian tissue contexts in vivo. The data serve as a foundation for future work using tissue-specific designs to further characterize these cells and their role in aging and disease. Abstract: Senescent cells accumulate during aging in a variety of tissues. Although scarce, they could influence tissue function non-cell-autonomously via secretion of a range of factors in their neighborhood. Recent studies support a role of senescent cells in age-related morbidity, including neurodegenerative diseases, cardiovascular pathologies, cancers, aging-associated nephrological alterations, chronic pulmonary disease and osteoarthritis, indicating that senescent cells could represent an interesting target for therapeutic exploitation across a range of pathophysiological contexts. In this article, we review data available to indicate which cell types can undergo senescence within various mammalian tissue environments and how these processes may contribute to tissue-specific pathologies associated with old age. We also consider markers used to identify senescent cells in vitro and in vivo . The data discussed may serve as an important starting point for an extended definition of molecular and functional characteristics of senescent cells in different organs and may hence promote the development and refinement of targeting strategies aimed at removing senescent cells from aging tissues.