A near infrared ratiometric fluorescent probe with aggregation induced emission (AIE) characteristics for hydrazine detection in vitro and in vivo. (April 2021)

• Record Type: Journal Article
• Authors: Zhang, Tiange; Zhu, Linlin; Lin, Weiying
• Is Part Of: Dyes and pigments. Volume 188(2021)
• Publication Date: 2021-04
• Subjects: Detection of hydrazine -- Near-infrared -- Ratiometric fluorescent probe -- Aggregation induced emission -- Zebrafish imaging; Dyes and dyeing -- Periodicals; Pigments -- Periodicals; 667.2
• DOI: 10.1016/j.dyepig.2021.109177
• Languages: English
• ISSNs: 0143-7208

Abstract

Abstract: Hydrazine (N2 H4 ) is widely used in agriculture and chemical industry because of its alkalinity and reducibility. However, inhalation of excessive hydrazine can cause extremely damage to human health. Herein, a near infrared ratiometric fluorescent probe PBT with aggregation induced emission (AIE) characteristics for hydrazine detection was reported. The probe PBT represents desirable characteristics including near-infrared (NIR), ratiometric detection, high selectivity, low detection limit (0.11 nM) as well as large Stokes shift (200 nm). Significantly, the probe PBT can be applied to detecting hydrazine vapor and imaging hydrazine in HepG2 cells and zebrafish. Highlights: We constructed a near infrared ratiometric fluorescent probe PBT for hydrazine detection. The probe PBT realized hydrazine detection with aggregation induced emission (AIE) characteristics. The probe PBT displays various virtues including low detection limit (0.11 nM), large Stokes shift (200 nm) and so on. Significantly, the probe PBT has been successfully applied to imaging of hydrazine in HepG2 cells and zebrafish.