Sex differences in group 2 innate lymphoid cell-dominant allergic airway inflammation. (December 2020)

• Record Type: Journal Article
• Authors: Wang, Cong; Xu, Zhi-Bin; Peng, Ya-Qi; Zhang, Hong-Yu; Yu, Qiu-Ning; Guo, Yu-Biao; Tan, Wei-Ping; Liu, Yang-Li; Meng, Xiang-Ci; Fang, Shu-Bin; Chen, Dong; Fu, Qing-Ling
• Is Part Of: Molecular immunology. Volume 128(2020:Dec.)
• Page Start: 89
• Page End: 97
• Publication Date: 2020-12
• Subjects: Asthma -- Allergic rhinitis -- Group 2 innate lymphoid cell -- Gender -- Testosterone; Immunochemistry -- Periodicals; Molecular biology -- Periodicals; Immunochemistry -- Periodicals; Allergy and Immunology -- Periodicals; Molecular Biology -- Periodicals; Immunochimie -- Périodiques; Biologie moléculaire -- Périodiques; Immunochemistry; Molecular biology; Periodicals; Electronic journals; 571.96
• DOI: 10.1016/j.molimm.2020.09.019
• Languages: English
• ISSNs: 0161-5890

Abstract

Highlights: Female mice with ILC2-dominant allergic airway inflammation exhibited higher levels of ILC2 levels compared to male mice. The treatment of testosterone significantly decreased the intracellular type 2 cytokines ILC2. Testosterone suppressed the proliferation of ILC2s. Abstract: There were gender differences in the prevalence and severity of allergic diseases. Group 2 innate lymphoid cells (ILC2s) were recently reported to play a critical role in allergic diseases. We investigated the sex-dependent differences in ILC2-dominant allergic airway inflammation model using T\B cell-deficient mice, and determined the gender differences of ILC2 levels in patients with asthma and allergic rhinitis. Female mice exhibited higher levels of inflammatory infiltration and large production of IL-5 and IL-13, especially for ILC2 levels compared to male mice with the induction of IL-33. However, no significant differences were found for the levels of circulating ILC2s between the genders of patients. The treatment of testosterone significantly decreased the intracellular type 2 cytokines in ILC2s and the proliferation of pure ILC2s in response to epithelial cytokines. Our study suggested the sex differences and the involvement of androgen on ILC2s in allergic diseases.