Inducible ablation of CD11c+ cells to determine their role in skin wound repair. Issue 1 (1st March 2021)

• Record Type: Journal Article
• Authors: Li, Zhi; Lamb, Rebecca; Coles, Mark C.; Bennett, Clare L.; Ambler, Carrie A.
• Is Part Of: Immunology. Volume 163:Issue 1(2021)
• Page Start: 105
• Page End: 111
• Publication Date: 2021-03-01
• Subjects: CD11c -- dendritic cells -- Langerhans cells -- skin -- wound repair; Immunology -- Periodicals
• DOI: 10.1111/imm.13312
• Languages: English
• ISSNs: 0019-2805

Abstract

Summary: Whether resident and recruited myeloid cells may impair or aid healing of acute skin wounds remains a debated question. To begin to address this, we examined the importance of CD11c+ myeloid cells in the early activation of skin wound repair. We find that an absence of CD11c+ cells delays wound closure and epidermal proliferation, likely due to defects in the activation of the IL‐23‐IL‐22 axis that is required for wound healing.