Amino Acid Coordination Driven Self‐Assembly for Enhancing both the Biological Stability and Tumor Accumulation of Curcumin. (25th November 2018)

• Record Type: Journal Article
• Authors: Li, Yongxin; Zou, Qianli; Yuan, Chengqian; Li, Shukun; Xing, Ruirui; Yan, Xuehai
• Is Part Of: Angewandte Chemie. Volume 130:Number 52(2018)
• Page Start: 17330
• Page End: 17334
• Publication Date: 2018-11-25
• Subjects: Aminosäuren -- Biologische Stabilität -- Curcumin -- Selbstassemblierung -- Tumortherapeutika; Chemistry -- Periodicals; 540
• DOI: 10.1002/ange.201810087
• Languages: English
• ISSNs: 0044-8249

Abstract

Abstract: Clinical translation of curcumin has been highly obstructed by the rapid degradation and poor tissue absorption of this agent. Herein, we report on the generation of supramolecular curcumin nanoagents through amino acid coordination driven self‐assembly to simultaneously increase the biological stability and tumor accumulation of curcumin. The biological stability of curcumin was significantly improved both through coordination and through molecular stacking. The sizes of these nanoagents can be readily manipulated to facilitate tumor accumulation. These favorable therapeutic features, together with high drug‐loading capacities and responses to pH and redox stimuli, substantially enhanced the antitumor activity of curcumin without discernible side effects. Hence, supramolecular curcumin nanoagents may hold promise in moving forward the clinical application of curcumin as an effective anticancer drug. Abstract : Spezial‐Agens im Einsatz : Supramolekulare Curcumin‐Nanoagentien werden durch Aminosäurekoordinations‐getriebene Selbstassemblierung hergestellt. Die biologische Stabilität von Curcumin wird durch Koordination wie auch durch molekulares Stapeln in den Nanoagentien deutlich verbessert. Diese positiven therapeutischen Eigenschaften erhöhen die Antitumoraktivität von Curcumin, ohne erkennbare Nebenwirkungen, deutlich.