Antibacterial gold nanoparticle-based photothermal killing of vancomycin-resistant bacteria. (4th July 2018)

• Record Type: Journal Article
• Authors: Wang, Sin-Ge; Chen, Yen-Chun; Chen, Yu-Chie
• Is Part Of: Nanomedicine. Volume 13:Number 12(2018)
• Page Start: 1405
• Page End: 1416
• Publication Date: 2018-07-04
• Subjects: antibacterial agents -- gold nanoparticles -- multivalent interactions -- near infrared (NIR) -- photothermal -- vancomycin -- vancomycin-resistant Enterococci; Nanotechnology -- Periodicals; Medical technology -- Periodicals; Nanotechnology -- Therapeutic use -- Periodicals; 610.28
• DOI: 10.2217/nnm-2017-0380
• Languages: English
• ISSNs: 1743-5889

Abstract

Aim: The extensive use of vancomycin has given rise to vancomycin-resistant bacterial strains, such as vancomycin-resistant Enterococci (VRE). We aim to explore potent medical treatments that can inhibit the growth of VRE.Materials & methods: Vancomycin-immobilized gold nanoparticles (Au@Van NPs) with polygonal shapes from one-pot reactions were generated within approximately 7 min.Results & discussion: The as-prepared Au NPs exhibit not only antibacterial capability but also photothermal competence. The temperature of the sample solution containing the as-prepared Au@Van NPs can be raised by approximately 15°C under irradiation by a near-infrared laser (λ = 808 nm) within 5 min.Conclusion: The required amount of vancomycin on the as-prepared Au@Van NPs combined with near-infrared irradiation for inhibiting VRE is approximately 16-fold lower than that of free-form vancomycin.