Machine Learning in Mass Spectrometric Analysis of DIA Data. Issue 21 (4th March 2020)

• Record Type: Journal Article
• Authors: Xu, Leon L.; Young, Adamo; Zhou, Audrina; Röst, Hannes L.
• Other Names: Wen Bo guestEditor.; Zhang Bing guestEditor.
• Is Part Of: Proteomics. Volume 20:Issue 21/22(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-03-04
• Subjects: data independent acquisition -- deep learning -- machine learning -- proteomics; Proteins -- Separation -- Periodicals; Bioinformatics -- Periodicals; Proteomics -- Periodicals; Genomes -- Periodicals; Molecular genetics -- Periodicals; 572.605
• DOI: 10.1002/pmic.201900352
• Languages: English
• ISSNs: 1615-9853

Abstract

Abstract: Liquid Chromatography coupled to Tandem Mass Spectrometry (LC‐MS/MS) based methods are currently the top choice for high‐throughput, quantitative measurements of the proteome. While traditional proteomics LC‐MS/MS methods can suffer from issues such as low reproducibility and quantitative accuracy due to its stochastic nature, recent improvements in acquisition protocols have resulted in methods that can overcome these challenges. Data‐independent acquisition (DIA) is a novel mass spectrometric method that does so by using a deterministic acquisition strategy. These new approaches will allow researchers to apply MS on more complex samples, however, existing heuristic and expert‐knowledge based methods will struggle with keeping pace of the increasing complexity of the resulting data. Deep learning (DL) based methods have been shown to be more adept at handling large amounts of complex data than traditional methods in many other fields, such as computer vision and natural language processing. Proteomics is also entering a phase where the size and complexity of the data will require us to look towards scalable and data‐driven DL pipelines.