Thirty Controversies and Considerations in Hypertrophic Cardiomyopathy. Issue 1 (2nd January 2021)

• Record Type: Journal Article
• Authors: Masri, Ahmad; Nazer, Babak; Al-Rashdan, Lana; Mannello, Meghan M.; Fischer, Katherine L.; Akhavein, Reyhaneh; Divanji, Punag; Song, Howard K.; Heitner, Stephen B.
• Is Part Of: Structural heart. Volume 5:Issue 1(2021)
• Page Start: 39
• Page End: 54
• Publication Date: 2021-01-02
• Subjects: Hypertrophic cardiomyopathy -- myectomy -- alcohol septal ablation -- sudden cardiac death -- imaging; Heart -- Diseases -- Periodicals; Congenital heart disease -- Periodicals; Cardiovascular system -- Diseases -- Periodicals; Cardiovascular Diseases; Cardiovascular system -- Diseases; Congenital heart disease; Heart -- Diseases; Periodicals; 616.12
• DOI: 10.1080/24748706.2020.1844926
• Languages: English
• ISSNs: 2474-8706

Abstract

ABSTRACT: More than 60 years after the first description of "asymmetric septal hypertrophy of the heart, " hypertrophic cardiomyopathy (HCM) as a disease has continued to provide clinicians and researchers fertile grounds for debate and investigation. HCM, as a complex disease requiring a multidisciplinary approach, runs the gamut of all we learned in medical school and beyond – physiology, clinical medicine, genetics, imaging, diagnostics, pharmacotherapies, electrophysiology, interventional cardiology, and cardiothoracic surgical interventions. In this review, we discuss 30 contemporary controversies and considerations in HCM.Abbreviations : HCM: hypertrophic cardiomyopathy; LVH: left ventricular hypertrophy; nHCM: non-obstructive hypertrophic cardiomyopathy; oHCM: obstructive hypertrophic cardiomyopathy; LVOTO: left ventricular outflow tract obstruction; MVA: mitral valve apparatus; P: phenotype; G: genotype; MYH7: myosin heavy chain 7; MYPBC3: myosin binding protein C, cardiac type; ECG: electrocardiogram; SCD: sudden cardiac death; MR: mitral regurgitation; LA: left atrium; AF: atrial fibrillation; CMR: cardiac magnetic resonance imaging; LGE: late gadolinium enhancement; ICD: implantable cardioverter-defibrillator; ECV: extracellular volume; CPET: cardio-pulmonary exercise testing; SRT: septal reduction therapy; FDR: first-degree relative; NYHA: New York Heart Association; DOAC: direct oral anticoagulants; OAC: oral anticoagulants; AAD: anti-arrhythmic drugs; NSVT: non-sustained ventricular tachycardia; ACC: American College of Cardiology; AHA: American Heart Association; ESC: European Society of Cardiology; LVEF: left ventricular ejection fraction; S-ICD: subcutaneous implantable cardioverter-defibrillator; IAS: inappropriate shock; AVB: atrio-ventricular block; CHB: complete heart block; VT: ventricular tachycardia; ASA: alcohol septal ablation; ATP: anti-tachycardia pacing; TE: thromboembolism; SAM: systolic anterior motion; LBBB: left bundle branch block.