Chaperna: linking the ancient RNA and protein worlds. Issue 1 (2nd January 2021)

• Record Type: Journal Article
• Authors: Son, Ahyun; Horowitz, Scott; Seong, Baik L.
• Is Part Of: RNA biology. Volume 18:Issue 1(2021)
• Page Start: 16
• Page End: 23
• Publication Date: 2021-01-02
• Subjects: RNA world -- protein world -- Chaperna -- chaperone RNA -- ribozyme -- protein folding -- protein aggregation -- molecular chaperones; RNA -- Periodicals; Molecular biology -- Periodicals; Molecular biology; RNA; Periodicals; 572.8805
• DOI: 10.1080/15476286.2020.1801199
• Languages: English
• ISSNs: 1547-6286

Abstract

ABSTRACT: As a mental framework for the transition of self-replicating biological forms, the RNA world concept stipulates a dual function of RNAs as genetic substance and catalyst. The chaperoning function is found intrinsic to ribozymes involved in protein synthesis and tRNA maturation, enriching the primordial RNA world with proteins of biological relevance. The ribozyme-resident protein folding activity, even before the advent of protein-based molecular chaperone, must have expedited the transition of the RNA world into the present protein theatre.