Catalytically Active Peptide–Gold Nanoparticle Conjugates: Prospecting for Artificial Enzymes. Issue 23 (25th March 2020)

• Record Type: Journal Article
• Authors: Mikolajczak, Dorian J.; Berger, Allison A.; Koksch, Beate
• Is Part Of: Angewandte Chemie international edition. Volume 59:Issue 23(2020)
• Page Start: 8776
• Page End: 8785
• Publication Date: 2020-03-25
• Subjects: artificial enzymes -- catalysis -- gold nanoparticles -- peptides -- self-assembly; Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201908625
• Languages: English
• ISSNs: 1433-7851

Abstract

Abstract: The self‐assembly of peptides onto the surface of gold nanoparticles has emerged as a promising strategy towards the creation of artificial enzymes. The resulting high local peptide density surrounding the nanoparticle leads to cooperative and synergistic effects, which result in rate accelerations and distinct catalytic properties compared to the unconjugated peptide. This Minireview summarizes contributions to and progress made in the field of catalytically active peptide–gold nanoparticle conjugates. The origin of distinct properties, as well as potential applications, are also discussed. Abstract : The attachment of peptides onto the surface of gold nanoparticles emerged as a promising strategy towards the creation of artificial enzymes. This Minireview summarizes the contributions to and progress made in the field of catalytically active peptide–gold nanoparticle conjugates over the past 15 years. The origin of distinct properties, as well as potential applications, are discussed.