Computational and Experimental Study of Turbo‐Organomagnesium Amide Reagents: Cubane Aggregates as Reactive Intermediates in Pummerer Coupling. Issue 8 (12th January 2021)

• Record Type: Journal Article
• Authors: Planas, Ferran; Kohlhepp, Stefanie V.; Huang, Genping; Mendoza, Abraham; Himo, Fahmi
• Is Part Of: Chemistry. Volume 27:Issue 8(2021)
• Page Start: 2767
• Page End: 2773
• Publication Date: 2021-01-12
• Subjects: computational chemistry -- density functional calculations -- Grignard reaction -- isotope effects -- reaction mechanism; Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.202004164
• Languages: English
• ISSNs: 0947-6539

Abstract

Abstract: The dynamic equilibria of organomagnesium reagents are known to be very complex, and the relative reactivity of their components is poorly understood. Herein, a combination of DFT calculations and kinetic experiments is employed to investigate the detailed reaction mechanism of the Pummerer coupling between sulfoxides and turbo‐organomagnesium amides. Among the various aggregates studied, unprecedented heterometallic open cubane structures are demonstrated to yield favorable barriers through a concerted anion‐anion coupling/ S−O cleavage step. Beyond a structural curiosity, these results introduce open cubane organometallics as key reactive intermediates in turbo‐organomagnesium amide mixtures. Abstract : The dynamic equilibria of organomagnesium reagents are known to be very complex, and the relative reactivity of their components is poorly understood. Herein, a combination of DFT calculations and kinetic experiments is employed to investigate the detailed reaction mechanism of the Pummerer coupling between sulfoxides and turbo‐organomagnesium amides.