An olfactory neuroblastoma presenting as posterior reversible leukoencephalopathy syndrome. Issue 6 (2nd November 2021)

• Record Type: Journal Article
• Authors: Doyle, James J.; Hashimie, Yasmeen; Metting, Austin
• Is Part Of: Proceedings. Volume 34:Issue 6(2021)
• Page Start: 724
• Page End: 725
• Publication Date: 2021-11-02
• Subjects: Adrenocorticotropin hormone -- Cushing's syndrome -- esthesioneuroblastoma -- olfactory neuroblastoma -- posterior reversible leukoencephalopathy; Medicine -- Periodicals; Medicine; Medicine -- Periodicals; Periodicals; Electronic journals; 616.005
• DOI: 10.1080/08998280.2021.1953878
• Languages: English
• ISSNs: 0899-8280

Abstract

Abstract: Olfactory neuroblastomas are rare malignancies of the nasal and sinus cavities. They have been associated with paraneoplastic syndromes due to secretion of adrenocorticotropin hormone (ACTH) or antidiuretic hormone. These associated paraneoplastic syndromes can present with a wide variety of symptoms that can make diagnosis of the underlying tumor difficult. Here we present the case of a 23-year-old woman who had a seizure due to the development of posterior reversible leukoencephalopathy syndrome because of secondary hypertension due to Cushing's syndrome, which was in turn found to be due to ectopic ACTH production from a metastatic olfactory neuroblastoma.