Treatment of relapsed and refractory multiple myeloma: recommendations from the International Myeloma Working Group. Issue 3 (March 2021)

• Record Type: Journal Article
• Authors: Moreau, Philippe; Kumar, Shaji K; San Miguel, Jesús; Davies, Faith; Zamagni, Elena; Bahlis, Nizar; Ludwig, Heinz; Mikhael, Joseph; Terpos, Evangelos; Schjesvold, Fredrik; Martin, Thomas; Yong, Kwee; Durie, Brian G M; Facon, Thierry; Jurczyszyn, Artur; Sidana, Surbhi; Raje, Noopur; van de Donk, Niels; Lonial, Sagar; Cavo, Michele; Kristinsson, Sigurdur Y; Lentzsch, Suzanne; Hajek, Roman; Anderson, Kenneth C; João, Cristina; Einsele, Hermann; Sonneveld, Pieter; Engelhardt, Monika; Fonseca, Rafael; Vangsted, Annette; Weisel, Katja; Baz, Rachid; Hungria, Vania; Berdeja, Jesus G; Leal da Costa, Fernando; Maiolino, Angelo; Waage, Anders; Vesole, David H; Ocio, Enrique M; Quach, Hang; Driessen, Christoph; Bladé, Joan; Leleu, Xavier; Riva, Eloisa; Bergsagel, Peter Leif; Hou, Jian; Chng, Wee Joo; Mellqvist, Ulf-Henrik; Dytfeld, Dominik; Harousseau, Jean-Luc; Goldschmidt, Hartmut; Laubach, Jacob; Munshi, Nikhil C; Gay, Francesca; Beksac, Meral; Costa, Luciano J; Kaiser, Martin; Hari, Parameswaran; Boccadoro, Mario; Usmani, Saad Z; Zweegman, Sonja; Holstein, Sarah; Sezer, Orhan; Harrison, Simon; Nahi, Hareth; Cook, Gordon; Mateos, Maria-Victoria; Rajkumar, S Vincent; Dimopoulos, Meletios A; Richardson, Paul G;
• Is Part Of: Lancet oncology. Volume 22:Issue 3(2021)
• Page Start: e105
• Page End: e118
• Publication Date: 2021-03
• Subjects: Oncology -- Periodicals; Neoplasms -- Periodicals; Cancérologie -- Périodiques; Oncologie; Oncology; Periodicals; Electronic journals; 616.994005
• DOI: 10.1016/S1470-2045(20)30756-7
• Languages: English
• ISSNs: 1470-2045

Abstract

Summary: This Policy Review presents the International Myeloma Working Group's clinical practice recommendations for the treatment of relapsed and refractory multiple myeloma. Based on the results of phase 2 and phase 3 trials, these recommendations are proposed for the treatment of patients with relapsed and refractory disease who have received one previous line of therapy, and for patients with relapsed and refractory multiple myeloma who have received two or more previous lines of therapy. These recommendations integrate the issue of drug access in both low-income and middle-income countries and in high-income countries to help guide real-world practice and thus improve patient outcomes.