Effectiveness and safety of ertapenem used in hospital-at-home units: data from Spanish Outpatient Parenteral Antimicrobial Therapy Registry. (September 2018)

• Record Type: Journal Article
• Authors: Sanroma, Pedro; Muñoz, Pedro; Mirón-Rubio, Manuel; Aguilera, Ana; Estrada, Oriol; García, Dora; González-Ramallo, Víctor J; Pajarón, Marcos; Sgaramella, Giusi A; González, Carmen R; Mujal, Abel; Abad, Aquilino; Solé, Anna; González, Soledad; Escalada, Carmen; Vitoria, Isabel; Gómez, María J; Parra, Juan J; Sampedro, Isabel; Pereda, Iliana
• Is Part Of: Future microbiology. Volume 13:Number 12(2018)
• Page Start: 1363
• Page End: 1373
• Publication Date: 2018-09
• Subjects: ertapenem -- hospital-at-home -- nursing homes -- OPAT -- Outpatient Parenteral Antimicrobial Therapy -- self-administration; Microbiology -- Research -- Periodicals; 616.9041
• DOI: 10.2217/fmb-2018-0065
• Languages: English
• ISSNs: 1746-0913

Abstract

Aim: To evaluate the effectiveness and safety of ertapenem in patients hospitalized at home.Patients & methods: Retrospective analysis of data from Spanish Outpatient Parenteral Antimicrobial Therapy (OPAT) registry.Results: Data from 1428 patients (median age 70 years; 5.4% institutionalized) and 1547 infectious processes (24% self-administration) were analyzed. Clinical cure or improvement was achieved in 93.8% of cases. Rate of related readmissions was 4.2%, of clinically important complications -3.9%, and of adverse drug reactions -3.2%. High comorbidity burden, contagion in nursing home and certain types of infection were associated with worse prognosis. Self-administration was effective and safe, except in case of nursing home-acquired infections.Conclusion: Ertapenem OPAT was effective and safe. Caregivers in nursing homes should be better trained in OPAT-related procedures.