Risk factors for disease severity and mortality of children with Covid-19: A study at a Vietnamese Children's hospital. Issue 10 (October 2022)

• Record Type: Journal Article
• Authors: Nguyen, Phung Nguyen The; Thuc, Tran Thanh; Hung, Nguyen Thanh; Thinh, Le Quoc; Minh, Ngo Ngoc Quang; Duy, Dang Quoc; Nhut, Tran Minh; Linh, Nguyen Bich Y; Tuan, Tran Minh; Giang, Ngo Hoang Lam; Tuyen, Vo Thi Minh
• Is Part Of: Journal of infection and chemotherapy. Volume 28:Issue 10(2022)
• Page Start: 1380
• Page End: 1386
• Publication Date: 2022-10
• Subjects: Pediatrics -- COVID-19 -- SARS-CoV-2 -- Risk factors; Chemotherapy -- Periodicals; Infection -- Periodicals; Communicable diseases -- Chemotherapy -- Periodicals; 615.5805
• DOI: 10.1016/j.jiac.2022.06.010
• Languages: English
• ISSNs: 1341-321X

Abstract

Abstract: Introduction: To find out risk factors for disease severity and mortality of pediatric COVID-19 in the fourth wave of COVID-19 in Vietnam. Methods: This retrospective cohort study was performed at Children's Hospital 1 from July to December 2021. All children with COVID-19 confirmed by a positive Realtime RT-PCR SARS-CoV-2 result and treated at COVID-19 department for at least 72 h were included. Results: Of the 850 cases admitting to COVID-19 department, 555 children with COVID-19 confirmed by positive RT-PCR and treated at our center for more than 72 h. Median age of confirmed cases was 22.3 (IQR: 3.2–88.6) months, 55.1% were male, and 84.5% had a history of close contact with confirmed COVID-19 patients. The rate of mild, moderate and severe/critical cases was 73, 7%, 9.0% and 17.3%, respectively. One hundred ninety-two children (34.6%) had underlying diseases, in which, neurologic disease was the most common underlying disease (7.9%). Underlying disease, dyspnea, elevated CRP >20 mg/L and elevated ferritin were independent factors related to severe illness. Twenty-point two percent of patients in our study needed respiratory support, including 22 invasive mechanical ventilation cases. Eighteen cases (3.2%) died because of severe comorbidities, poor response to treatment. Conclusions: In our study, the severe/critical and mortality rates in pediatric COVID-19 cases were relatively high. All fatal cases had severe comorbidities. Underlying disease, dyspnea, and elevated inflammatory markers were independent factors related to severity in pediatric COVID-19 cases.