Changes in somatosensory evoked potentials elicited by lateral cerebellar nucleus deep brain stimulation in the naïve rodent. (24th August 2022)

• Record Type: Journal Article
• Authors: Hermann, John K.; Borseth, Ashley; Pucci, Francesco G.; Toth, Carmen; Hogue, Olivia; Chan, Hugh H.; Machado, Andre G.; Baker, Kenneth B.
• Is Part Of: Neuroscience letters. Volume 786(2022)
• Publication Date: 2022-08-24
• Subjects: Deep brain stimulation -- Stroke rehabilitation -- Dentatothalamocortical pathway -- Cortical excitability -- Somatosensory evoked potentials; Neurology -- Periodicals; Neurology -- Periodicals; Research -- Periodicals; Neurologie -- Périodiques; Neuroanatomie -- Périodiques; Neuropharmacologie -- Périodiques; Neurophysiologie -- Périodiques; Neurology; Periodicals; Electronic journals; 617.48
• DOI: 10.1016/j.neulet.2022.136800
• Languages: English
• ISSNs: 0304-3940

Abstract

Highlights: Chronic rodent model for recording sciatic nerve somatosensory evoked potentials. Stimulation of lateral cerebellar nucleus enhanced somatosensory evoked potentials. SSEPs are not ideal for programming lateral cerebellar nucleus stimulation. Abstract: Deep brain stimulation (DBS) of the deep cerebellar nuclei has been shown to enhance perilesional cortical excitability and promote motor rehabilitation in preclinical models of cortical ischemia and is currently being evaluated in patients with chronic, post-stroke deficits. Understanding the effects of cerebellar DBS on contralateral sensorimotor cortex may be key to developing approaches to optimize stimulation delivery and treatment outcomes. Using the naïve rat model, we characterized the effects of DBS of the lateral cerebellar nucleus (LCN) on somatosensory evoked potentials (SSEPs) and evaluated their potential use as a surrogate index of cortical excitability. SSEPs were recorded concurrently with continuous 30 Hz or 100 Hz LCN DBS and compared to the DBS OFF condition. Ratios of SSEP peak to peak amplitude during 100 Hz LCN DBS to DBS OFF at longer latency peaks were significantly>1, suggesting that cortical excitability was enhanced as a result of LCN DBS. Although changes in SSEP peak to peak amplitudes were observed, they were modest in relation to previously reported effects on motor cortical excitability. Overall, our findings suggest that LCN output influences thalamocortical somatosensory pathways, however further work is need to better understand the potential role of SSEPs in optimizing therapy.