Research progress on the synthesis, structural modification and biological activity of stigmatellin A. (13th August 2022)

• Record Type: Journal Article
• Authors: Wang, Wanqiang; Liu, Hongfu; Yan, Jin; Jiang, Yani; Cheng, Hua; Wang, Dawei
• Is Part Of: Tetrahedron. Volume 120(2022)
• Publication Date: 2022-08-13
• Subjects: Natural products -- Stigmatellin -- Organic synthesis -- Structural modification -- Biological evaluation; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tet.2022.132880
• Languages: English
• ISSNs: 0040-4020

Abstract

Abstract: Stigmatellin A, a natural product with a chromone ring structure, is a specific inhibitor of the mitochondrial respiratory chain cytochrome bc1 complex at the Qo site. In the last two decades, researchers have carried out extensive and in-depth organic synthesis studies and biological evaluations of this molecule. Herein, we review the recent progress on the synthesis and structural modification of stigmatellin A and its application in fungicide discovery. This review is expected to provide valuable clues for the synthesis of natural products that contain the chromone motif. Graphical abstract: Stigmatellin A, a natural product bearing a chromone moiety as the core skeleton, has been identified as a representative inhibitor that binds to the Qo site of the cytochrome bc 1 complex. Due to its unique structure and diverse biological activities, numerous researchers have conducted systematic and extensive investigations. This paper mainly described the development and biological activities of stigmatellin A, and then summarized the recent results of its synthesis and structural modifications. Image 1