Encoding and decoding NF-κB nuclear dynamics. (August 2022)

• Record Type: Journal Article
• Authors: Wibisana, Johannes Nicolaus; Okada, Mariko
• Is Part Of: Current opinion in cell biology. Volume 77(2022)
• Publication Date: 2022-08
• Subjects: NF-κB Nuclear Factor Kappa B -- IKK IκB kinase -- IκBα NF-κB inhibitor α -- LPS Lipopolysaccharide -- TNF Tumor necrosis factor -- TLR Toll-like receptor -- IL Interleukin -- NGS Next generation sequencing -- ATAC-seq Assay of transposase accessible chromatin with sequencing -- ChIP-seq histone chromatin immunoprecipitation with sequencing -- LLPS Liquid-liquid phase separation -- BET Bromodomain and extra-terminal domain -- H3K27ac Histone 3 lysine 27 acetylation -- SE Super enhancer -- TE Typical enhancer; Cells -- Periodicals; Cytology -- Periodicals; Cell Biology -- Periodicals; Biology -- Periodicals; Cells -- Periodicals; Review Literature -- Periodicals; Cell Biology; Biology; Cells; Review Literature; Cellules -- Périodiques; Cytologie -- Périodiques; Electronic journals; 571.6
• DOI: 10.1016/j.ceb.2022.102103
• Languages: English
• ISSNs: 0955-0674

Abstract

Abstract: The NF-κB signaling pathway is crucial for cellular responses to environmental factors. Several studies have tried to decipher the mechanism of cells utilizing this pathway for information transfer and accurately encoding extracellular information that is translated into unique transcriptional programs. This fine-tuned encoding is possible owing to the complex regulatory mechanisms in the NF-κB pathway and is relayed through the nuclear dynamics of the NF-κB transcription factor. The "message" is then decoded through transcriptional and post-transcriptional regulation leading to stimulus-dependent phenotypes. Here, we reviewed recent advances on how different environmental stimuli are encoded and decoded by cells to produce distinct transcriptional responses and the important analytical techniques used in NF-κB research. Highlights: Cells exploit the NF-κB pathway to respond to environmental changes. Signal encoding and decoding are strictly controlled via the NF-κB pathway. Features of NF-κB nuclear dynamics reflect dose- and stimuli-sensing cell mechanism. NF-κB dynamics and chromatin dynamics together regulate gene expression.