Biological features of inflammatory breast cancer in North Africa: burden and research priorities. (11th September 2018)

• Record Type: Journal Article
• Authors: Mejri, Nesrine; Benna, Houda El; M'ghirbi, Fehmi; Labidi, Soumaya; Daoud, Nouha; Boussen, Hamouda
• Is Part Of: Breast cancer management. Volume 7:Number 2(2018)
• Publication Date: 2018-09-11
• Subjects: biology -- inflammatory breast cancer -- North Africa; Breast -- Cancer -- Periodicals; Breast -- Cancer -- Treatment -- Periodicals; 616.9944905
• DOI: 10.2217/bmt-2018-0002
• Languages: English
• ISSNs: 1758-1923

Abstract

We aimed to review all published literature reporting biological data about inflammatory breast cancer (IBC) in populations from North Africa.Methods: We reviewed all studies that evaluated biological features of IBC in six North African countries between 1990 and 2017. Among 118 screened studies, 13 were included, none about Mauritania/Libya.Results: Across the studies, hormonal receptors were positive in 46–69% of cases, reaching 83% in Algeria. HER2 was overexpressed in 25–39% of cases. Recombinant human C protein expression was the highest in Egyptian patients (87%) compared with other North African populations. Using mRNA expression recombinant human C protein was expressed in 83% of Tunisian patients. WISP3 gene expression showed positive immunohistochemistry staining in 17% and mRNA expression in 26.8% of IBC.Conclusion: Biological aspects of IBC across North Africa show important similarities and differences.