Feedforward and output–feedback control of the cell distribution in chemostat yeast fermentations. Issue 7 (2022) - Jerono, P.
Abstract: A two-degree-of-freedom control strategy is developed and experimentally validated for a set-point change along a desired trajectory of the cell distribution in yeast fermentation. Based on a mathematical model of yeast growth and cell population dynamics, an inversion-based feedforward controller is designed, utilizing a transformation between the biomass concentration and the cell distribution at the equilibrium points. To take disturbances and model inaccuracies into account, the controller is extended by a feedback control law. The controller is applied to a lab-scale stirred tank reactor with Saccharomyces cerevisiae.