Decoding the LncRNA transcriptome of esophageal cancer: identification of clinically relevant LncRNAs. (7th September 2018)

• Record Type: Journal Article
• Authors: Khadirnaikar, Seema; Narayanan, Sathiya Pandi; Shukla, Sudhanshu Kumar
• Is Part Of: Biomarkers in medicine. Volume 12:Number 10(2018)
• Page Start: 1083
• Page End: 1093
• Publication Date: 2018-09-07
• Subjects: biomarkers -- diagnosis -- esophageal cancer -- LncRNA -- prognosis -- prognostic signature; Biochemical markers -- Periodicals; 610.28
• DOI: 10.2217/bmm-2018-0032
• Languages: English
• ISSNs: 1752-0363

Abstract

Aim: LncRNAs may act as promising biomarkers in esophageal cancer (EC). Here, we illustrate the LncRNA profile and their clinical relevance in EC.Patients & Methods: In this study, we utilized the Cancer Genome Atlas RNA-sequencing and clinical data from 186 patients and 13 normal samples. Various statistical and gene set enrichment analysis (GSEA) were performed to identify the biomarkers.Results: In a differential expression analysis, we identified a total of 127 LncRNAs with more differentially expressed in EC compared with normal and showed their function using guilt-by-association analysis. We generated a LncRNAs prognostic signature for EC. Using Cox regression analysis, we showed the prognostic ability of LncRNAs' prognostic signature in training and test-cohort (p-value < 0.01).Conclusion: In summary, we explored the LncRNA expression profile and their clinical utility in EC patients.