Clinical significance of microRNA-21 expression in disease progression of patients with hepatocellular carcinoma. (7th September 2018)

• Record Type: Journal Article
• Authors: Yoon, Jun Sik; Kim, Gyeonghwa; Lee, Yu Rim; Park, Soo Young; Tak, Won Young; Kweon, Young-Oh; Park, Jung Gil; Lee, Hye Won; Han, Young Seok; Ha, Heon Tak; Chun, Jae Min; Jang, Se Young; Hur, Keun
• Is Part Of: Biomarkers in medicine. Volume 12:Number 10(2018)
• Page Start: 1105
• Page End: 1114
• Publication Date: 2018-09-07
• Subjects: disease progression -- hepatocellular carcinoma -- microRNA-21 -- microRNA-31 -- prognosis -- survival -- therapeutics; Biochemical markers -- Periodicals; 610.28
• DOI: 10.2217/bmm-2018-0096
• Languages: English
• ISSNs: 1752-0363

Abstract

Aim: Aberrant microRNA (miR) expression is associated with hepatocellular carcinoma (HCC).Materials & methods: Here, we investigated the clinical significance of miR-21 and miR-31 for HCC-specific prognostic effect. HCC patients (n = 93) who underwent liver biopsy or surgical resection were enrolled, and HCC tissues and paired adjacent nontumor liver tissues were collected and analyzed for miRs expression.Results: MiR-21 expression was significantly upregulated in HCC tissues relative to nontumor tissues. Both miR-21 and miR-31 expression in HCC tissues did not predict overall survival; however, miR-21 was considered an independent predictor of disease progression together with portal vein thrombosis and higher Barcelona Clinical Liver Cancer stage.Conclusion: Elevated miR-21 expression might represent a biomarker for HCC prognosis.