NT-proBNP levels and mortality in a general population-based cohort from Turkey: a long-term follow-up study. (7th September 2018)

• Record Type: Journal Article
• Authors: Simsek, Mustafa Aytek; Degertekin, Muzaffer; Turer Cabbar, Ayca; Aslanger, Emre; Ozveren, Olcay; Aydın, Sinan; Mutlu, Bulent; Erol, Cetin
• Is Part Of: Biomarkers in medicine. Volume 12:Number 10(2018)
• Page Start: 1073
• Page End: 1081
• Publication Date: 2018-09-07
• Subjects: all-cause mortality -- cardiovascular epidemiology -- cardiovascular mortality -- general population -- NT-proBNP; Biochemical markers -- Periodicals; 610.28
• DOI: 10.2217/bmm-2018-0120
• Languages: English
• ISSNs: 1752-0363

Abstract

Aim: We investigated the relationship between NT-ProBNP and mortality in a general population-based cohort.Methods & Results: A total of 2021 out of 4650 participants from previously published HAPPY study were included. Mean follow-up was 84.5 ± 10.4 months. After adjusting for risk factors, high levels of LogNT-proBNP predicted all-cause death (HR: 3.23; 95% CI: 2.20–4.75; p < 0.001) and cardiovascular death (HR: 3.85; 95% CI: 2.37–6.26; p < 0.001). Regression analysis revealed that LogNT-proBNP was an independent predictor of all-cause death (HR: 2.85; 95% CI: 1.91–4.24; p < 0.001) and cardiovascular death (HR: 3.02; 95% CI: 1.84–4.95; p < 0.001).Conclusıon: Our study showed that in long term follow-up, NT-proBNP is associated with increased all-cause and cardiovascular mortality